A Score for Predicting Freedom from Progression of Children and Adolescents with Hodgkin Lymphoma

Several studies have examined the prognostic performance of therapeutic groups (TG) and early responses to therapy on positron emission tomography/computed tomography (PET/CT) in children adolescents with classical Hodgkin lymphoma (cHL); less research has been performed molecular parameters at diagnosis. The aim present study was devise a scoring system based TG criteria for predicting freedom from progression (FFP) 133 patients: 63.2% males; 14 years median age (interquartile range (IQR) 11.9–15.1); cHL (108 nodular sclerosis (NS) subtype) treated according AIEOP LH-2004 protocol; 5.55 (IQR 4.09–7.93) follow-up. CHL progressed or relapsed 37 patients (27.8%), FFP 0.89 = 0.59–1.54), (10.5%) died. FPR (final rank) model associates biological HLA-G SNP 3027C/A (numerical point assigned (pt) 1) absolute neutrophil count (>8 × 109/L, pt 2) as variables (TG3, 3). Results score analyses suggested that (Kaplan–Meier curves, log-rank test trends) better than model. At diagnosis, high-risk classified rank 4 5 identified 18/22 who relapse during